- Scram Kitty and His Buddy on Rails
- Scribblenauts Unlimited
- Scribblenauts Unmasked: A DC Comics Adventure
- Secret of Mana [I/1993]
- Severed
- Shadow of the Eternals
- Shadow Puppeteer
- Shakedown: Hawaii
- Shantae and the Pirate's Curse
- Shantae: Half-Genie Hero
- Shantae: Risky's Revenge
- Shapes of Gray
- Shiftlings
- Shiny the Firefly
- Shovel Knight
- Shovel Knight: Specter of Torment
- Shuttle Rush
- Sin and Punishment: Star Successor
- SiNG Party
- Six Sides of the World
- Sky Force Anniversary
- Skylanders: Giants
- Skylanders Imaginators
- Skylanders: SuperChargers
- Skylanders: SWAP Force
- Skylanders Trap Team
- Slain: Back from Hell
- Slender: The Arrival
- Smurfs 2, The
- Sniper Elite V2
- Sonic & All-Stars Racing Transformed
- Sonic Boom: Rise of Lyric
- Sonic: Lost World
- Soon Shine
- Soul Axiom
- Space Hulk: Ascension
- Space Hunted
- SpaceRoads
- Spelunker
- Spheroids
- Spikey Walls
- Spin the Bottle: Bumpie's Party
- Splatoon
- SpongeBob SquarePants: Plankton's Robotic Revenge
- ESPN Sports Connection
- Sportsball
- Spot the Differences!
- Spy Chameleon: RGB Agent
- Squids Odyssey
- Star Fox Guard
- Star Fox Zero
- Star Ghost
- Star Sky
- Star Wars Pinball
- Stardew Valley
- Starwhal: Just the Tip
- Stealth Inc. 2: A Game of Clones
- SteamWorld Dig
- SteamWorld Heist
- Stick It to the Man!
- Stonecutter, The
- Super Mario 3D World
- Super Mario 64
- Super Mario Maker
- Super Mario RPG
- Super Meat Boy
- Super Smash Bros. for Nintendo 3DS and Wii U
- Super Toy Cars
- Suspension Railroad Simulator
- Swapper, The
- Swindle, The
- Swords & Soldiers
- Swords & Soldiers 2
- Tachyon Project
- Tallowmere
- Tank! Tank! Tank!
- Teenage Mutant Ninja Turtles [III/2013]
- Tekken Tag Tournament 2
- Tengami
- Terraria
- Teslagrad
- Tetrobot and Co.
- Thomas Was Alone
- TNT Racers
- Toby: The Secret Mine
- Toki Tori
- Toki Tori 2
- Tokyo Mirage Sessions ♯FE
- Tom Clancy's Ghost Recon: Phantoms
- Tom Clancy's Splinter Cell: Blacklist
- Toto Temple Deluxe
- Transformers Prime: The Game
- Transformers: Rise of the Dark Spark [I/2014]
- Trine
- Trine 2: Complete Story
- Tumblestone
- Turbo: Super Stunt Squad
- Turtle Tale
- Two Brothers
- Typoman